WebBaseline cytokine levels were comparable between Gsdme −/− and Gsdmd −/−;Gsdme −/− mice and were similar to levels in WT animals . After LPS challenge, the IL-1 family cytokines were similarly elevated in Gsdme −/− mice as in WT mice but did not increase in Gsdmd −/−;Gsdme −/− animals. LPS induced elevated IL-6 and CXCL1 ... WebJun 23, 2024 · GSDME-meditated pyroptosis is usually induced by drugs. Chemotherapeutic drugs, such as doxorubicin and cisplatin, activate caspase-3 and then cleave GSDME [ 25 ]. Other drugs such as metformin enhance B-cell lymphoma-2-associated X expression and cytochrome C release, subsequently mediating caspase-3/GSDME noncanonical …
BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME ...
WebDec 8, 2024 · GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs). While, how … WebIn the article titled “ GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis ”, published on pages 40–47, Issue 2, Volume 3 of Blood Science, the … ticket hero ch 1
Inflammation and hematopoietic stem cells aging - ResearchGate
WebJul 25, 2024 · 1. INTRODUCTION. Hematopoietic stem cells (HSCs) are a rare but long-lived population of blood cells. 1 HSCs lie on the top of the blood system and give rise to … WebFeb 18, 2024 · Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of inflammation. To test the hypothesis that GSDME-mediated pyroptosis … WebAug 15, 2024 · Simultaneous silencing of GSDME in mice attenuated acute kidney injury and inflammation . These studies provide a potential new strategy for the treatment of inflammatory diseases. ... Peripheral blood differential counts were normal, and blood smears showed no hematopoietic abnormalities. This is primarily due to GSDMD … ticket holders clipart